President Donald Trump confirmed on Saturday that Ayatollah Ali Khamenei, the supreme leader of Iran and the country’s highest political and religious authority, was killed during Israeli and U.S. strikes in the country.

“Khamenei, one of the most evil people in History, is dead. This is not only Justice for the people of Iran, but for all Great Americans, and those people from many Countries throughout the World, that have been killed or mutilated by Khamenei and his gang of bloodthirsty THUGS,” Trump wrote. 

Israeli media reported he was killed in an Israeli strike on his compound in Tehran. He was 86.

Khamenei had led Iran since 1989, succeeding Ayatollah Ruhollah Khomeini, who took over the country as part of his Islamic Revolution in 1979. Over more than three decades in power, he oversaw major shifts in Iran’s domestic politics, military posture and regional strategy, moves that resulted in the Islamic Republic becoming the world’s leading exporter of terrorism through proxies such as Hamas and Hezbollah.

As supreme leader, Khamenei exercised ultimate authority over the armed forces, judiciary, state broadcasting and key political appointments. He maintained final say over defense and foreign policy, including Iran’s nuclear program, and appointed top commanders of the Islamic Revolutionary Guard Corps. 

The IRGC became the primary instrument of Khamenei’s rule. He cultivated and empowered it for decades, and the IRGC in turn underwrote his domestic authority and Iran’s regional ambitions across Iraq, Syria, Lebanon, Yemen and Gaza through what he called the “Axis of Resistance.”

His foreign policy was defined by two poles of opposition: the United States, which he called Iran’s “No. 1 enemy,” and Israel, whose destruction he repeatedly called for in rhetoric that mixed geopolitical calculation with antisemitic tropes. Under his leadership, Iran became what the U.S. State Department designated the world’s foremost state sponsor of terrorism.

No successor has been publicly named, and with much of the IRGC’s senior leadership also reported killed in Saturday’s strikes, the question of who fills the vacuum left by Khamenei will mark a pivotal moment in Iran’s history.