A day before U.S.-Iran nuclear talks, Vice President JD Vance urged the Iranian regime on Wednesday to take President Donald Trump’s diplomatic overtures “seriously,” cautioning that the president has “a number of tools at his disposal” to keep the “craziest and worst regime in the world” from acquiring nuclear weapons.

Vance made the comments while appearing on Fox News’ “America’s Newsroom” after being asked about Trump’s comments at the State of the Union on Tuesday night, during which the president underscored his willingness to use force while acknowledging his preference for a diplomatic solution. 

“The president has been as crystal clear as he could be: Iran can’t have a nuclear weapon. That would be the ultimate military objective if that’s the route that he chose,” Vance said. “That is what we’re trying to accomplish, as the president said, through the preferred route of diplomacy, but it’s very simple: We have to get to a position where Iran, the largest state sponsor of terrorism in the world, cannot threaten the world with nuclear terrorism.”

“I think most Americans understand that you can’t let the craziest and worst regime in the world have nuclear weapons. That’s what the president is accomplishing, that’s what the president has set as our goal,” he continued. “He’s going to try to accomplish it diplomatically, but as we all know, the president has a number of other tools at his disposal to ensure this doesn’t happen. He’s shown a willingness to use them, and I hope the Iranians take it seriously in their negotiations tomorrow because that’s certainly what the president prefers.”

Asked if that meant the president’s position is that Iranian Supreme Leader Ayatollah Ali Khamenei must be removed, Vance reiterated that the administration is “hopeful that we’re able to come to a good resolution without the military, but if we have to use the military, the president, of course, has that right as well.”

“I think the president ultimately will make the decision about how to ensure Iran does not have a nuclear weapon, but we’re sitting down having another round of diplomatic talks with the Iranians, trying to reach a reasonable settlement, but a reasonable settlement towards what end?” Vance asked. “Iran can’t have a nuclear weapon. It’s very simple. I think the supreme leader and everybody in their system should understand it. We’ve been crystal clear.”

Sen. Lindsey Graham (R-SC), meanwhile, warned on Wednesday that he would not support a Trump administration-brokered deal with Iran that would allow the regime to continue enriching some uranium as part of its nuclear program.

“If media reports are true that there is a consideration of allowing Iran to have very small enrichment of uranium for face-saving purposes: screw that,” Graham wrote on X. “This regime is made up of religious Nazis that are the largest state sponsor of terrorism. The regime has American blood on its hands and they have killed over 30,000 of their citizens simply because they demand the end to their oppression.”

Graham added that he “could care less about efforts to save face for this regime. I would like to see the people of Iran change the regime – it’s long overdue. I hope help is on the way.”