An Iranian missile struck northern Israel early Friday, injuring 58 residents and damaging 300 homes in Zarzir, a Bedouin town near Nazareth.

A woman in her 30s was moderately injured by shrapnel in her back, and the rest of the injuries were minor, according to Magen David Adom emergency services.

Zarzir Mayor Ataf Grifat described to Israeli media at the site “great destruction. … I heard the explosion from my house and I thought it was flying, even though I live hundreds of [yards] from the scene.” 

“One house was totally destroyed. About 300 homes were damaged from the blast that hit windows, doors and roofs. Whoever was in a safe room was saved, and those who were outside were injured,” Grifat added.

Many of the missiles Iran has lobbed at Israel had cluster munitions attached to them, which break into pieces when they explode, such that there are more impact sites. 

Soon after the attack, President Donald Trump issued a threat to Iran: “Watch what happens to these deranged scumbags today.” 

“They’ve been killing innocent people all over the world for 47 years, and now I, as the 47th president of the United States of America, am killing them. What a great honor it is to do so!” the president wrote on Truth Social.

Iranian state TV said that new Supreme Leader Mojtaba Khamenei released his first statement since being named to the position earlier this week, after his father, Ayatollah Ali Khamenei, was killed in the initial strikes of the ongoing war with Iran, which began on Feb. 28. In the statement, Khamenei vowed that Iran “will not neglect avenging the blood of [the] martyrs.” 

The remarks were read by a TV presenter. Khamenei has yet to appear in public since ascending to the leadership, and was reportedly injured in airstrikes.

”The popular demand is to continue our effective defense and make the enemy regret,” the statement attributed to Khamenei said. “The lever of blocking the Strait of Hormuz must continue to be used.”

The Strait of Hormuz is the sole maritime artery through which oil can be exported from the Gulf to the open sea. While the U.S. has destroyed large Iranian vessels that could block the strait, smaller Iranian boats were laced with explosives and others are thought to have set mines in the area.

Israeli Prime Minister Benjamin Netanyahu said in a press conference on Thursday that “the new tyrant, Mojtaba, the puppet of the Revolutionary Guards, cannot show his face in public.” 

Israel and the U.S. “have achieved enormous accomplishments that are changing the balance of power in the Middle East and beyond … establishing Israel’s status as a power that is stronger than ever,” Netanyahu stated. “We are crushing the nuclear infrastructure, the missile and launcher array, the headquarters of oppression, the regime’s power centers, and many more targets.” 

Netanyahu said that the timing of the war was important because Iran was taking “accelerated action to restore the nuclear and missile programs … If we had not acted immediately, within a few months Iran’s death industry would have been immune to any strike.” 

Netanyahu also called again for the Iranian people to rise up against their leaders: “The moment when you can embark on a new path of freedom … is approaching. We stand by you, we are helping you. But at the end of the day, it depends on you. It is in your hands.” 

The Israeli prime minister also hinted at budding relations with other countries in the Middle East, “alliances that until a few weeks ago would have seemed unimaginable,” he said.

The press conference was Netanyahu’s first since the war with Iran began, with reporters asking questions via video link, amid restrictions on gatherings due to the security situation. 

Since the beginning of Operation Lion’s Roar, Magen David Adom has treated 854 people with physical injuries resulting from missile fire, including 12 fatalities and 628 who were injured en route to shelter.

Iranian ballistic missiles struck Soroka Hospital in Beersheba in southern Israel and sites in the Tel Aviv area on Thursday morning, wounding 89, including three seriously.

A missile struck the hospital’s old surgical building, severely damaging it and causing what a Soroka spokesperson described as “extensive damage in various areas” of the hospital complex. The surgical building had been recently evacuated in light of the war, and patients and staff had been moved to areas with reinforced walls. Injuries from the strike were light, hospital representatives said.

Soroka is the largest hospital in the Negev, such that the strike left a large swath of Israel without a functioning major medical center. Other hospitals in the area, including Barzilai Medical Center in Ashkelon and Assuta Medical Center in Ashdod, prepared to take in patients from buildings that were damaged. Magen David Adom provided four intensive care buses, able to transport a total of 23 ICU patients and 50 lightly injured casualties.

Israeli Foreign Minister Gideon Sa’ar wrote that “The Iranian regime fired a ballistic missile at a hospital. The Iranian Regime deliberately targets civilians. The Iranian regime is committing war crimes. The Iranian regime has no red lines.”

Prime Minister Benjamin Netanyahu posted on X that “Iran’s terrorist dictators shot missiles at Soroka Hospital in Beersheba and the civilian population in the center of the country. We will make the dictators in Tehran pay the full price.”

Israeli Defense Minister Israel Katz said in a statement that the price would be to destabilize the Islamic Republic’s regime.

“The prime minister and I instructed the IDF to increase the force of the attacks against strategic targets in Iran and against governmental targets in Tehran to remove the threats to the State of Israel and undermine the Ayatollahs’ regime,” he stated.

Iranian news agency IRNA claimed that the target of the strike was an IDF intelligence outpost in Beersheba’s HiTech Park, which is over a mile away from the hospital. A television channel tied to the Islamic Revolutionary Guard Corps said that the missile was aimed at a “military hospital” in response to strikes on “civilian hospitals” in Gaza.

In the same 30-missile barrage, Iranian missiles struck a school in Holon. No children were present, because schools have been closed across Israel since Friday, but three elderly residents of adjacent buildings were wounded in serious condition, in addition to 62 others with minor to moderate injuries.

Another missile struck near the Ramat Gan Diamond Exchange, abutting Tel Aviv, causing minor injuries to 21 people and damage to 20 buildings in the neighborhood, which includes some of Israel’s tallest buildings.

Shrapnel struck Sheba Medical Center, Israel’s biggest hospital, also in Ramat Gan.

Overnight, the IDF intercepted several drones launched by Iran at Israel towards central and northern Israel. 

Jordanian authorities reported that an Iranian drone fell in a shopping center north of Amman, damaging a car and a bus station. Syrian media reported that an Iranian drone was shot down over the country.

The IDF struck an inactive nuclear reactor near Arak in Iran early Thursday after sending warnings to civilians in the area. The IDF Spokesperson’s Office said the strike included “the structure of the reactor’s core seal, which is a key component in plutonium production.”

“The strike targeted the component intended for plutonium production, in order to prevent the reactor from being restored and used for nuclear weapons development,” the IDF Spokesperson’s Office said.

The IDF also gave details of strikes on the active nuclear site in Natanz, which “contained components and specialized equipment used to advance nuclear weapons development and projects designed to accelerate the regime’s nuclear program.” 

In addition, 40 IAF fighter jets struck dozens of military targets in Tehran and other parts of the country, including factories manufacturing ballistic missile and air-defense components, as well as air-defense batteries, surface-to-surface missile storage sites, radar systems and other targets.

IDF Chief of Staff Lt.-Gen. Eyal Zamir sent a letter of encouragement to IDF soldiers and commanders on Thursday, saying that they are “writing a new chapter in history for the State of Israel and the entire Middle East.”

”Thanks to a decisive and impressive surprise opening strike, we have achieved tremendous goals: We eliminated the regime’s command echelons, delivered a deep blow to the capabilities used for the Iranian nuclear program, identified and struck missile launchers, and we are continuing and increasing the strength of our operations as necessary,” Zamir wrote.

Iranian news reported that the country’s military shot down a second Israeli Hermes Drome. The IDF confirmed that Iran downed the first UAV a day earlier.

Israel’s Home Front Command loosened restrictions on Israelis on Wednesdays, allowing people to return to workplaces with safe rooms and for up to 30 people to attend synagogue at a time. Schools and kindergartens remained closed.

A poll published by the Israel Democracy Institute found that 70% of Israelis support the campaign launched against Iran last week, while 10% support the campaign but think the timing is wrong and 13.5% oppose it. Among Israeli Jews, 82% support the strikes, whereas only 11% of Israeli Arabs do, according to the poll. Jewish Israelis across the political spectrum support the operation: 57% of those who self-identify as left-wing, 75% of centrists and 90% on the right.

Though in past polls, most Jewish Israelis did not think Israel should strike Iran without help from the U.S., this week 69% thought it was the right decision. In addition, 68% of Jewish Israelis thought that Netanyahu’s motivation behind launching the operation against Iran was security-related, while 68% of Arab Israelis thought it was political.

The poll was conducted this Sunday-Tuesday among 594 Israelis, with a 3.61% margin of error.