Iranian ballistic missiles struck Soroka Hospital in Beersheba in southern Israel and sites in the Tel Aviv area on Thursday morning, wounding 89, including three seriously.

A missile struck the hospital’s old surgical building, severely damaging it and causing what a Soroka spokesperson described as “extensive damage in various areas” of the hospital complex. The surgical building had been recently evacuated in light of the war, and patients and staff had been moved to areas with reinforced walls. Injuries from the strike were light, hospital representatives said.

Soroka is the largest hospital in the Negev, such that the strike left a large swath of Israel without a functioning major medical center. Other hospitals in the area, including Barzilai Medical Center in Ashkelon and Assuta Medical Center in Ashdod, prepared to take in patients from buildings that were damaged. Magen David Adom provided four intensive care buses, able to transport a total of 23 ICU patients and 50 lightly injured casualties.

Israeli Foreign Minister Gideon Sa’ar wrote that “The Iranian regime fired a ballistic missile at a hospital. The Iranian Regime deliberately targets civilians. The Iranian regime is committing war crimes. The Iranian regime has no red lines.”

Prime Minister Benjamin Netanyahu posted on X that “Iran’s terrorist dictators shot missiles at Soroka Hospital in Beersheba and the civilian population in the center of the country. We will make the dictators in Tehran pay the full price.”

Israeli Defense Minister Israel Katz said in a statement that the price would be to destabilize the Islamic Republic’s regime.

“The prime minister and I instructed the IDF to increase the force of the attacks against strategic targets in Iran and against governmental targets in Tehran to remove the threats to the State of Israel and undermine the Ayatollahs’ regime,” he stated.

Iranian news agency IRNA claimed that the target of the strike was an IDF intelligence outpost in Beersheba’s HiTech Park, which is over a mile away from the hospital. A television channel tied to the Islamic Revolutionary Guard Corps said that the missile was aimed at a “military hospital” in response to strikes on “civilian hospitals” in Gaza.

In the same 30-missile barrage, Iranian missiles struck a school in Holon. No children were present, because schools have been closed across Israel since Friday, but three elderly residents of adjacent buildings were wounded in serious condition, in addition to 62 others with minor to moderate injuries.

Another missile struck near the Ramat Gan Diamond Exchange, abutting Tel Aviv, causing minor injuries to 21 people and damage to 20 buildings in the neighborhood, which includes some of Israel’s tallest buildings.

Shrapnel struck Sheba Medical Center, Israel’s biggest hospital, also in Ramat Gan.

Overnight, the IDF intercepted several drones launched by Iran at Israel towards central and northern Israel. 

Jordanian authorities reported that an Iranian drone fell in a shopping center north of Amman, damaging a car and a bus station. Syrian media reported that an Iranian drone was shot down over the country.

The IDF struck an inactive nuclear reactor near Arak in Iran early Thursday after sending warnings to civilians in the area. The IDF Spokesperson’s Office said the strike included “the structure of the reactor’s core seal, which is a key component in plutonium production.”

“The strike targeted the component intended for plutonium production, in order to prevent the reactor from being restored and used for nuclear weapons development,” the IDF Spokesperson’s Office said.

The IDF also gave details of strikes on the active nuclear site in Natanz, which “contained components and specialized equipment used to advance nuclear weapons development and projects designed to accelerate the regime’s nuclear program.” 

In addition, 40 IAF fighter jets struck dozens of military targets in Tehran and other parts of the country, including factories manufacturing ballistic missile and air-defense components, as well as air-defense batteries, surface-to-surface missile storage sites, radar systems and other targets.

IDF Chief of Staff Lt.-Gen. Eyal Zamir sent a letter of encouragement to IDF soldiers and commanders on Thursday, saying that they are “writing a new chapter in history for the State of Israel and the entire Middle East.”

”Thanks to a decisive and impressive surprise opening strike, we have achieved tremendous goals: We eliminated the regime’s command echelons, delivered a deep blow to the capabilities used for the Iranian nuclear program, identified and struck missile launchers, and we are continuing and increasing the strength of our operations as necessary,” Zamir wrote.

Iranian news reported that the country’s military shot down a second Israeli Hermes Drome. The IDF confirmed that Iran downed the first UAV a day earlier.

Israel’s Home Front Command loosened restrictions on Israelis on Wednesdays, allowing people to return to workplaces with safe rooms and for up to 30 people to attend synagogue at a time. Schools and kindergartens remained closed.

A poll published by the Israel Democracy Institute found that 70% of Israelis support the campaign launched against Iran last week, while 10% support the campaign but think the timing is wrong and 13.5% oppose it. Among Israeli Jews, 82% support the strikes, whereas only 11% of Israeli Arabs do, according to the poll. Jewish Israelis across the political spectrum support the operation: 57% of those who self-identify as left-wing, 75% of centrists and 90% on the right.

Though in past polls, most Jewish Israelis did not think Israel should strike Iran without help from the U.S., this week 69% thought it was the right decision. In addition, 68% of Jewish Israelis thought that Netanyahu’s motivation behind launching the operation against Iran was security-related, while 68% of Arab Israelis thought it was political.

The poll was conducted this Sunday-Tuesday among 594 Israelis, with a 3.61% margin of error.

Israeli Prime Minister Benjamin Netanyahu has staked everything — his legacy, his global standing, his relationships with world powers — on defending Israel against the threat of a nuclear-armed Iran.

The topic has dominated nearly every major address the prime minister has given, from U.N. General Assembly speeches to addresses to Congress, for the last 15 years. And over the last four days, Israel has been forced to put into action a plan that was years in the making — one that could profoundly reshape the Middle East in the days and months to come.

As Israeli journalist Amit Segal notes, “And so Netanyahu’s life mission became dismantling Iran’s nuclear ambitions. Over the years, in meetings with U.S. presidents, the incumbent president would raise the Palestinian issue, while Netanyahu would focus on the Iranian threat. Menachem Begin destroyed Iraq’s nuclear reactor in 1981, Ehud Olmert did the same to Syria’s reactor in 2007, and Netanyahu vowed to do likewise with Iran.”

The writer Douglas Murray forecasted exactly this situation 13 years ago, speaking at the Cambridge Union: “When Israel is pushed to the situation it will be pushed to of having to believe [Iran] mean[s] it, and when every bit of jiggery pokery behind the scenes runs out, and when the U.N. and distinguished figures have run out of time, and Iran is about to produce its first bomb,” Murray said at the time, “Israel will strike.”

Israel’s Friday morning strikes came as the Trump administration’s announced 60-day deadline for negotiations expired, and following intelligence reports indicating that Iran was weeks away from nuclear capabilities — as Murray predicted.

What has ensued is the deadliest and most destructive direct conflict between Israel and Iran in history. At least 24 Israelis have been confirmed killed since Friday night in strikes around the country. 

For the last three nights, Israelis around the country have stumbled into safe rooms and public shelters as Iran bombarded the country with ballistic missiles.

And while the barrages, meant to overwhelm Israel’s defensive systems, have inflicted damage across the country, the vast majority of the roughly 350 missiles fired from Iran and Yemen over the last 72 hours have been intercepted by Israel’s missile-defense systems.

With Iran believed to still have nearly 2,000 ballistic missiles in its arsenal, the ongoing air raid sirens and attacks around the country could continue for weeks, stranding the more than 150,000 Israelis currently abroad as Israeli airspace remains closed. Israel’s Channel 12 reported today that repatriation flights may begin in the coming days, allowing stranded Israelis to return home. 

In the last 72 hours, more than a decade of warnings have crystallized into reality, a culmination of years of diplomatic efforts, proxy battles and intelligence operations. What happens in the ensuing days and weeks will not only determine the strategic balance of the region — it has the potential to reset the global order.